Dedicated to clinical and basic research on optic nerve injury repair for over 20 years, he established the interdisciplinary field of oculo-nasal minimally invasive surgery. He pioneered a minimally invasive interventional treatment system for optic nerve diseases, completing over 8,000 cases of endoscopic transethmoidal optic canal decompression (ETOCD)—the highest volume globally. He proposed a novel theory on the activation of residual optic nerve function, authored the Expert Consensus on Endoscopic Transnasal Optic Canal Decompression for Traumatic Optic Neuropathy in China, and served as Editor-in-Chief of Oculo-Nasal Minimally Invasive Surgery (People's Medical Publishing House).

Integrating medicine and engineering through mutually driven clinical and basic research, he addressed bottleneck challenges in optic nerve regeneration and repair for traumatic optic neuropathy (TON). His innovations include pioneering a biomimetic large animal model for TON, developing neural microtubes for the directional induction of axonal regeneration (a "13th Five-Year Plan" achievement), establishing key technologies for intra-optic nerve sheath microenvironment regulation and aptamer-targeted therapy, and inventing the world's first 3D orbital surgical navigation system and multispectral functional pupillometer.

He was awarded the First Prize of the Zhejiang Provincial Science and Technology Progress Award in 2023. In July 2024, he established the Provincial Key Laboratory for Key Technologies in the Functional Reconstruction of Eye-Brain Neural Pathways. His titles and honors include Expert Recipient of the State Council Special Allowance, Outstanding Talent of the Zhejiang Provincial "Ten Thousand Talents Program", Young and Middle-Aged Expert with Outstanding Contributions in Zhejiang Province, 9th National Young and Middle-Aged Expert with Outstanding Contributions to Health, Leading Health Talent of Zhejiang Province, 5th "People's Renowned Doctor", and High-Level Innovative Health Talent of Zhejiang Province.

He leads the "Optic Nerve Biological Microtube Development and Application Innovation Team," recognized as a 2024 Wenzhou High-Level Innovation Team (Scientific and Technological), and the "Precision Minimally Invasive Orbital Surgery" team, recognized as a 2019 Wenzhou High-Level Innovation Team (Leading Category). He received the APAO Achievement Award in 2019.

As Chief Scientist, he secured funding from the National "13th Five-Year" and "14th Five-Year" Key Research and Development Programs. He has served as Principal Investigator for over 10 projects, including those funded by the National Natural Science Foundation of China and the Zhejiang Provincial Major Research and Development Program. He has published over 110 articles as the first or corresponding author, including 62 SCI-indexed papers in top-tier journals such as Ophthalmology, Am J Ophthalmol, Mol Neurodegener, and Br J Ophthalmol. His publications have garnered 1,066 independent citations, averaging 7.25 independent citations per paper.